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Because all CNS depressants work by slowing the brain's activity, when an individual stops taking them, the brain's workings can rebound and race out of control, possibly resulting in seizures and other harmful consequences.

A physical symptom of dependence is tolerance, meaning higher levels are needed to achieve the same calming effect.

Using CNS depressants with these other substances—particularly alcohol—can slow breathing, or slow both the heart and respiration, possibly resulting in death.

Other health risks of sedative use include: Very significant levels of physiological dependence marked by both tolerance and withdrawal can develop in response to the sedatives.

Symptoms of psychological dependence include needing the drug to function and being obsessed with obtaining the drug.

Symptoms of withdrawal include: To be clinically diagnosed with having a Sedative, Hypnotic, or Anxiolytic Use Disorder, there must be a problematic pattern of impairment or distress, with at least two of the following symptoms within the previous 12-month period: Patients addicted to these medications should undergo medically supervised detoxification as the dose must be gradually tapered off.

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Often the abuse of barbiturates and benzodiazepines occurs in conjunction with the abuse of another substance or drug, such as alcohol or cocaine.

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